Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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Open in a separate window. Incorporation of antitubercular drug isoniazid in pharmaceutically accepted microemulsion: A review of cellulose ether in hydrophilic matrices for oral controlled release dosage forms. Air was extracted from the chamber by an exhaust fan. Published online Nov 6. The mixture was stirred to obtain a homogeneous dispersion. The particles in the melt suspension were dispersed and existed as individual, separated particles.

Other research groups have reported similar results that the drug release hp,c decreased with increasing molecular weight for low-molecular-weight HPMCs and became independent of molecular weight for hppmc HPMCs 29 — Spray congealing of selected molten mixtures was carried out using a laboratory scale spray congealer Mobile MinorNiro, Denmark.

Assessment of Molten Mixture Sprayability The sprayability of the molten mixture was assessed by evaluating its product yield obtained after the spray congealing process. The batch reproducibility study indicated that the formulation methodology employed IPA granulation was found to be suitable for manufacturing good quality CR matrix tablets of isoniazid.

Because hypromellose solution is a non-newtonian solution and exhibits pseudoplastic, more specifically, thixotropic behavior, various test methods are available, and the results of different methods and viscosmeters do not necessarily correspond to each other.


Influence of surfactants on drug release from hydroxypropylmethylcellulose matrices. Furthermore, batch to batch variations of HPMC exist and can potentially alter the rheological properties of the polymer melt suspensions, necessitating readjustment of process parameters during manufacturing to achieve the desired final product. The closer the samples were in the scores plot, the more similar they were.

Please review our privacy policy. In the nomenclature of HPMC grades, an initial letter K, E, F identifies the different substitutions of methoxyl and hydroxypropyl groups in the polymer.

Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies

It was observed that the viscosity of the formulations generally increased proportionally with HPMC concentration but inversely with hpmx. The content of such third party sites is not within our control, and we cannot and will not take responsibility for the information or content.

The reason for higher HPMC release in 0. Views Read Edit View history. The formulations were developed using wet granulation technology. Received Apr 15; Accepted Aug Even though these techniques are useful for extracting information from the different viscosity profiles, it may be increasingly complex and time-consuming when many formulations are involved and the plots overlap with one another.

On the other hand, an increase in temperature increased the kinetic energy of the molecules, resulting in greater molecular mobility and reduction in viscosity. Viscosity profiles of the various formulations with increasing temperature.

Particle flocculation by adsorbing polymers. It is interesting to note that the viscosity profiles of the formulations with high HPMC concentration were grouped according to the E- F- and K-series with the exception of KM.


Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

At lower applied compression force, there might be insufficient tablet strength and greater level of porosity void spaces within the matrix which allowed a greater liquid penetration in to the matrix, causing immediate dissolution of the drug within the matrix that enhanced the diffusivity of the drug out of the matrix. This website provides links to other websites owned by third parties. Encapsulation of antihypertensive drugs in cellulose-based matrix microspheres: The surface plots also provided other useful information as discussed below.

In vitro release data pertaining to reproducibility studies were compared by f 2 metric similarity factor values. The K deg for isoniazid in various formulations ranged from 5.

Batch Reproducibility Three batches of each formulation were prepared and their quality and respective release characteristics were evaluated under the same conditions as prescribed in previous sections. A simple equation for description of solute release. Effect of hpkc size in flocculation. The reason for initial higher release and decrease in i4m rate of isoniazid with time can be explained as follows.


The particle shapes of the different HPMC grades were found to be variable, albeit generally elongated Fig. Metronidazole BP gradea yellowish crystalline powder, was obtained from Sunward Pharmaceutical, Singapore.

The formulated tablets were evaluated for their physical properties and in vitro release characteristics.